The case for an adverse interaction between aspirin and non-steroidal anti-inflammatory drugs: is it time to believe the hype?

wice in the past year, headlines across the nation have ighlighted the publication of studies suggesting that nonteroidal anti-inflammatory drugs (NSAIDs) inhibit the ardioprotective effects of aspirin (1,2). Based on these esults, some experts have strongly recommended that atients avoid taking these medications in combination 3,4). These studies and the resultant publicity place cliniians in an uncomfortable position and raise the natural uestion whether the current evidence supports this degree f concern.